Meet the Faculty
Kattesh V. Katti MSc.Ed, Ph.D, DSC, FRSC.
CuratorsвЂ™ Distinguished Professor of Biological Engineering, Physics and Radiology
- Phone: 573-882-5656
- E-mail: KattiK@health.missouri.edu
- Address: Cancer Nanotechnology Platform, 103 Alton Building Laboratories;301 Business Loop 70 W; Columbia, Missouri 65212, USA
- Website: http://web.missouri.edu/~kattik/katti/katti
- Ph.D Indian Institute of Science
Our ongoing research activities involve the development of engineered nanoconstructs with capabilities for site specific targeting of receptor proteins over expressed in breast, pancreatic and prostate cancers. The overall goal has been to target tumor specific peptide functionalized gold nanoparticles on cancer cells/receptors and lesions to be able to detect breast, pancreatic and prostate cancers in early stages through sophisticated molecular imaging. The high Z value of gold is being capitalized for the X ray CT imaging of various tumors. The efficacy of our engineered gold nanoparticles toward endocytosis within cancer cells has allowed accurate detection of circulating tumor cells (CTCs) from breast, pancreatic and prostate cancers, via Photoacoustic techniques, with detection limits reaching 1-10 cancer cells. Radioactive gold nanoparticles (Au-198/199) are inherently therapeutic; through our comparative oncology efforts, we have succeeded in developing targeted therapeutic gold nanoparticles which have shown unprecedented therapeutic efficacy reaching >85% in reduction of tumor volumes in both small animals and in dogs which mimic human tumors. We are also developing nanoparticles-based new therapeutic approaches for the treatment of age related macular degeneracy (AMD) and Pseudo Xanthoma Elasticum (PXE).
Green nanotechnology is at the focal point of Katti's approach to pursuing research in nanotechnology as he strongly believes in total elimination of toxic chemicals either for the synthesis or as byproducts in the production of engineered nanoparticles. Toward this end, phytochemicals occluded within plants, herbs or from various sources from mother nature are being used in developing 100% green processes for the development of nano constructs for use in a plethora of medical, agricultural, hygienic and alternate energy (biofuels) applications.